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open-appsec can be deployed as an add-on for NGINX or Kong Gateway to provide protection to any applications and APIs served by NGINX Reverse Proxy, Webserver or Kong Gateway.
The open-appsec agent attaches itself to the traffic being proxied by the Proxy Server or API server.
If the server serves applications locally, and does not serve as a proxy between an exposed domain and an internal one - open-appsec can still inspect the traffic if you change the port for the local applications to a higher port, and add a proxy rule between the exposed listening domain and port, to the same local machine at a higher port.